Anderlecht 1 - 0 APOEL
(Anderlecht menang agregat 2-0)
Borussia Moenchengladbach 2 - 2 Schalke
(Schalke menang 3-3)
Roma 2 - 1 Lyon
(Lyon menang agregat 5-4)
Manchester United 1 - 0 Rostov
(United menang agregat 2-1)
Ajax 2 - 0 Copenhagen
(Ajax menang agregat 3-2)
Krasnodar 0 - 2 Celta Vigo
(Celta Vigo menang agregat 4-1)
Besiktas 4 - 1 Olympiakos
(Beskitas menang agregat 5-2)
Genk 1 - 1 Gent
(Genk menang agregat 6-3)
